REFERENCES

TissueArray.Com tissue microarrays and products from US Biomax have been referenced in over 1200 scientific papers since 2006, with 600 since 2013. Our products have been used in several papers from top journals such as Nature and Cell. To view the latest references, please check our listings on Google Scholar, or view a complete list.

Selected References

Top 200 by Impact Factor:

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
CM Rudin, S Durinck, EW Stawiski, JT Poirier, … — Nat. Genet., 2012
… microarrays. SCLC tissue microarrays were obtained from US Biomax (LC703, LC802a, LC1009 and LC10010a) for IHC and FISH as fresh-cut slides. The four …
Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion
G Wang, A Lunardi, J Zhang, Z Chen, … — Nat. Genet., 2013
… at the Memorial Sloan-Kettering Cancer Center (MSKCC) or purchased from US Biomax, and stained in Pathology and Molecular Cytology Core Facilities …
Frequent truncating mutations of STAG2 in bladder cancer
DA Solomon, JS Kim, J Bondaruk, SF Shariat, … — Nat. Genet., 2013
… spotted in triplicate, (ii) ovarian cancer tumor microarray OV1921 from US Biomax containing …
Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
CS Lee, A Bhaduri, A Mah, WL Johnson, … — Nat. Genet., 2014
… Each SCC used for allelic discrimination contained ≥80% tumor tissue (US Biomax). Genomic DNA was isolated from all specimens using the DNeasy Blood and …
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
KL Scott, O Kabbarah, MC Liang, E Ivanova, … — Nature, 2009
… PA802 pancreatic carcinoma and ME1001 melanoma tissue microarrays were from US Biomax. FISH was prepared following standard protocols. BAC RP11-437P15 was …
Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271
AD Boiko, OV Razorenova, M van de Rijn, SM Swetter, … — Nature, 2010
… upon intradermal injection in Paraffin melanoma tissue array slides (US Biomax) containing 80 1.5-mm tissue cores from primary and metastatic …
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
X Su, D Chakravarti, MS Cho, L Liu, … — Nature, 2010
… carcinomas (LC1005) and mammary adenocarcinomas (BR480) were obtained from US …
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
M Jaskelioff, FL Muller, JH Paik, E Thomas, … — Nature, 2011
… determine telomerase activity with a Quantitative Telomerase Detection kit (US Biomax) following the manufacturer’s recommendations. 0.5 μg total protein …
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
CJ Ceol, Y Houvras, J Jane-Valbuena, S Bilodeau, … — Nature, 2011
… green counterstain was used. Melanoma tissue microarrays were obtained from US Biomax (ME1003 and ME482). A modified visual semiquantitative method was used …
Suppression of lung adenocarcinoma progression by Nkx2-1
MM Winslow, TL Dayton, RG Verhaak, C Kim-Kiselak, … — Nature, 2011
… and HMGA2 in human lung adenocarcinoma we stained a tissue microarray (US Biomax, LC1921) for these proteins using the antibodies described above. …
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
R Straussman, T Morikawa, K Shee, M Barzily-Rokni, … — Nature, 2012
… normal skin, naevi and melanomas (ME1004a and ME803a) were purchased from US Biomax. Colorectal cancer TMAs were prepared as described …
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110
J Li, V D'Angiolella, ES Seeley, S Kim, … — Nature, 2013
… 4 . Tissue microarray. Pancreatic tissue arrays were purchased from US Biomax (PA1001 and PA207). Immunohistochemical staining was performed as …
RNAi screens in mice identify physiological regulators of oncogenic growth
S Beronja, P Janki, E Heller, WH Lien, … — Nature, 2013
… Skin squamous cell cancer tissue array (SK802a) was obtained from US Biomax Immunohistochemistry preparations were developed using ImmPRESS …
PVT1 dependence in cancer with MYC copy-number increase
YY Tseng, BS Moriarity, W Gong, R Akiyama, … — Nature, 2014
… multiple organ tumour tissue microarray slides (BC00119) were obtained from US Biomax. In situ hybridization used digoxigenin-labelled PVT134 probe according …
Fructose-1,6-bisphosphatase opposes renal carcinoma progression
B Li, B Qiu, DS Lee, ZE Walton, … — Nature, 2014
… microarray slides (KD801, KD208, BC07114, BC07115, LV804, and LV208 from US Biomax) were deparaffinized by baking slides at 60 °C for 30 min. The slides …
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion
M Overholtzer, AA Mailleux, G Mouneimne, G Normand, … — Cell, 2007
… cleaved caspase-3 staining. Human tumor tissue arrays were purchased from US …
USP10 regulates p53 localization and stability by deubiquitinating p53
J Yuan, K Luo, L Zhang, JC Cheville, … — Cell, 2010
… Microarray The tissue arrays of Kidney cancer samples were purchased from US Biomax (KD 2083, KD991t, KD804, KD241, and KD208t). Immunohistochemical …
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
CG Lian, Y Xu, C Ceol, F Wu, … — Cell, 2012
… other TMA (ARY, US Biomax) contained 79 evaluable specimens including 27 primary melanomas and 27 melanoma metastases. …
Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth
L Cheng, Z Huang, W Zhou, Q Wu, … — Cell, 2013
… Sections of GBM specimens or tissue arrays (Duke Brain Tumor Center and US Biomax) were immunostained for a-SMA to mark pericytes or CD31 to label ECs, …
Hijacking the neuronal NMDAR signaling circuit to promote tumor growth and invasion
L Li, D Hanahan, , — Cell, 2013
… microarrays were purchased from US Biomax http://www.US Biomax/ (Pancreatic cancer: PA481. Ovarian cancer: OV241a. Breast cancer: BCA961. Glioma: …
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
WJ Israelsen, TL Dayton, SM Davidson, BP Fiske, … — Cell, 2013
… in human breast cancers was analyzed in three tissue microarrays: US Biomax BR1504, one multitissue TMA-containing tissue from the archives of the …
Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors
BM Emerling, JB Hurov, G Poulogiannis, KS Tsukazawa, … — Cell, 2013
… we show that a subset of breast cancers express high levels of the type 2 phosphatidylinositol-5-phosphate 4-kinases α and/or β (PI5P4Kα and β) and …
Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation
N Pencheva, CG Buss, J Posada, T Merghoub, … — Cell, 2014
… blinded immunohistochemical analyses of cutaneous melanoma lesions from the US Biomax TMA (K C) into mice that were administered a normal chow or a chow …
Programmed translational readthrough generates antiangiogenic VEGF-Ax
SM Eswarappa, AA Potdar, WJ Koch, Y Fan, … — Cell, 2014
… arrays contained 1.5-mm by 5-mm thick samples (US Biomax). The adenocarcinoma array contained samples from 30 cases and 5 healthy individuals. Sections …
Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin
A Chandrasekaran, A Srinivasan, R Raman, K Viswanathan, … — Nat. Biotechnol., 2008
… interacting with a long 2-6 Normal human trachea (US Biological) and lung (US Biomax) tissue sections were deparaffinized, rehydrated and incubated with 1% …
Inactivation of myocardin and p16 during malignant transformation contributes to a differentiation defect
M Milyavsky, I Shats, A Cholostoy, R Brosh, … — Cancer Cell, 2007
… in situ hybridization using the Soft Tissue Cancer tissue array (SO801, US Biomax), and detection of myocardin and vimentin using cancer profiling array …
Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia
G Guasch, M Schober, HA Pasolli, EB Conn, … — Cancer Cell, 2007
… and 41 female genital SQCCs (UV241, UV801, PE241, PE801) were obtained from US Biomax, Rockeville, MD. Paraffin slides were deparaffinized and stained with …
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
RH Wang, K Sengupta, C Li, HS Kim, … — Cancer Cell, 2008
… antibodies. The tissue array of breast cancer samples was purchased from US Biomax (Cat. BR1002). Immunohistochemical staining against SIRT1 (Cat. 07-131, …
Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression
JA Reuter, S Ortiz-Urda, M Kretz, J Garcia, … — Cancer Cell, 2009
… For tissue microarrays, nonoverlapping skin SCC arrays (SK801 and SK802; US Biomax) and a panel of SCC in situ patient samples were deparaffinized, …
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment
DA Chan, TL Kawahara, PD Sutphin, HY Chang, … — Cancer Cell, 2009
… hypoxia treatment. Colon and breast tissue microarrays were purchased from US Biomax. All human tissues for the tissue microarrays were obtained with …
Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate
L Wang, R Liu, W Li, C Chen, … — Cancer Cell, 2009
… information. Tissue microarray samples came from the University of Michigan, US Biomax (US Biomax, Rockville, MD), and Target Biotech (Target Biotech, …
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
M Garofalo, G Di Leva, G Romano, G Nuovo, … — Cancer Cell, 2009
… OH). Other 72 cancer and normal (24) lung tissues were purchased from US Biomax The human tissues were obtained and studied in strict adherence to …
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
HS Kim, K Patel, K Muldoon-Jacobs, KS Bisht, … — Cancer Cell, 2010
… in breast cancer specimens from a commercially available tissue array (US Biomax), as compared with normal breast tissue samples ( Figure 7A). In …
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
HS Kim, A Vassilopoulos, RH Wang, T Lahusen, … — Cancer Cell, 2011
… Specimens The tissue array of breast cancer samples was purchased from US Biomax (Cat. BR1002). All tissues were collected with the donor being informed …
The crosstalk of mTOR/S6K1 and Hedgehog pathways
Y Wang, Q Ding, CJ Yen, W Xia, … — Cancer Cell, 2012
… at time of enrollment. The multiple tissue microarrays were purchased from US Biomax (BC00112 and MTU241; Rockville, MD, …
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
JH Tsai, JL Donaher, DA Murphy, S Chau, … — Cancer Cell, 2012
… of 99 human breast carcinoma and matched metastases were purchased from US Biomax The TMA contained human tissues obtained with informed consent …
The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas
Z Xiao, Q Jiang, J Willette-Brown, S Xi, … — Cancer Cell, 2013
… with their proximal and distal adjacent lung tissues was purchased from US Biomax. The human lung squamous cell carcinoma cell line SW-900 (HTB-59) was …
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis
L Wang, Z Zhao, MB Meyer, S Saha, … — Cancer Cell, 2014
… breast tumors including lymph node metastasis specimens (C) on the US Biomax BR723 …
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry
X Feng, MS Degese, R Iglesias-Bartolome, JP Vaque, … — Cancer Cell, 2014
… Johns Hopkins School of Medicine. Normal skin samples were purchased from US Biomax and …
PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis
H Zheng, M Shen, YL Zha, W Li, … — Cancer Cell, 2014
… PKD1 (pY95-PKD1) and S11-SNAIL in a breast tumor tissue microarray (US Biomax BC081120). χ2 = 10.0, p = 0.0016 by χ2 test. (D) Representative IHC …
MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis
S Anand, BK Majeti, LM Acevedo, EA Murphy, … — Nat. Med., 2010
… carcinoma tissue array and normal human tissue array were purchased from US Biomax. In situ hybridization was performed as previously described37 with a …
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
V Barry-Hamilton, R Spangler, D Marshall, S McCauley, … — Nat. Med., 2010
… Proteogenex, Cooperative Human Tissue Network (Vanderbilt University), US Biomax and University of Massachusetts Cancer Center Tumor Bank. Each …
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20
M Blank, Y Tang, M Yamashita, SS Burkett, … — Nat. Med., 2012
… with matching normal tissues and the lymphoma tissue array 801 were from US Biomax. Immunohistochemistry of the array was analyzed and quantified by a …
A versatile genome-scale PCR-based pipeline for high-definition DNA FISH
M Bienko, N Crosetto, L Teytelman, S Klemm, … — Nat. Methods, 2013
… control tissue arrays with ten cores were purchased from US …
Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
Y Fan, A Arif, Y Gong, J Jia, … — Nat. Cell Biol., 2012
… from healthy controls or subjects with myocardial infarction (BioChain, US Biomax and BioCat) were de-paraffinized and rehydrated, and subjected to …
The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis
K Zhang, CA Corsa, SM Ponik, JL Prior, … — Nat. Cell Biol., 2013
… microarrays of breast cancer tissues and normal breast tissues were from US Biomax (Rockville). Tissue samples were stained with mouse monoclonal SNAIL1 …
Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation
Y Fan, AA Potdar, Y Gong, SM Eswarappa, … — Nat. Cell Biol., 2014
… specimens from subjects with several tumour types including astrocytoma (US Biomax and BioChain), or healthy controls, were de-paraffinized and rehydrated, …
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase
B Ma, Y Chen, L Chen, H Cheng, … — Nat. Cell Biol., 2014
… breast cancer tissue microarrays were purchased from US Biomax. These tissue microarrays consist of 203–204 analysable cases of invasive breast carcinoma …
BMP7 Induces Dormancy of Prostatic Tumor Stem Cell in Bone
A Kobayashi, H Okuda, F Xing, PR Pandey, … — J. Exp. Med., 2011
… Human Subjects. A prostate cancer tissue microarray was obtained from US Biomax The tissue microarray slide contained 41 samples from prostate …
Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration
NA Evensen, C Kuscu, HL Nguyen, K Zarrabi, … — J. Natl. Cancer Inst., 2013
… microarray samples (BR804, BC08013a, and BR10010a) were purchased from US Biomax Inc (Rockville, MD). SNAP Pull-Down Assay and Proteomic Analysis. …
FBXW7 mutations in melanoma and a new therapeutic paradigm
IT Aydin, RD Melamed, SJ Adams, M Castillo-Martin, … — J. Natl. Cancer Inst., 2014
… on formalin-fixed and paraffin-embedded tissue microarray sections (M1004a; US Biomax, Rockville, …
AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts
J Zhang, SI Park, MC Artime, JM Summy, … — J. Clin. Invest., 2007
… tissue arrays. Human prostate tissue arrays were purchased from Cybrdi and US Biomax Each array spot was 1 mm in diameter and 5 μm in thickness. Two …
FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2
T Zuo, R Liu, H Zhang, X Chang, … — J. Clin. Invest., 2007
… Department of Pathology Tissue Bank, Zymed Laboratories Inc., and US Biomax Antibodies. Affinity …
The role of keratinocyte-specific Smad2 loss in skinsquamous cell carcinomas
KE Hoot, J Lighthall, G Han, SL Lu, … — J. Clin. Invest., 2008
… skin SCC and normal skin samples were from a human SCC tissue array (US Biomax) and collected from surgically resected specimens between the years 2000 …
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation
B Zheng, JH Jeong, JM Asara, YY Yuan, … — Mol. Cell, 2009
… Analysis Human melanoma tissue microarray was obtained from US Biomax (Rockville MD). Formalin-fixed paraffin-embedded tissue microarray was …
The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling
DS Micalizzi, KL Christensen, P Jedlicka, RD Coletta, … — J. Clin. Invest., 2009
… Transduction Laboratories), and Smad3 (5 μg/ml; Zymed). Tumor arrays (US Biomax) were stained using Six1 (1:100; Atlas antibodies) and Smad3 (5 μg/ml; …
Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis
M Qiao, Y Wang, X Xu, J Lu, … — Mol. Cell, 2010
… The tissue microarray slides were purchased from US Biomax, Inc (Rockville, MD). Slides were deparaffinized in xylene (thrice for 10 min) …
Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells
L He, A Ingram, AP Rybak, D Tang, … — J. Clin. Invest., 2010
… cancer tissue microarray (TMA) slides (US Biomax) contained 5 normal cervical tissues, 5 cancer-adjacent normal cervical tissues SIPL1 …
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
EC Pacheco-Pinedo, AC Durham, KM Stewart, AM Goss, … — J. Clin. Invest., 2011
… (48 adenocarcinomas) along with normal adult lung tissue (catalog BC041115, US Biomax) and …
FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway
F Kottakis, C Polytarchou, P Foltopoulou, I Sanidas, … — Mol. Cell, 2011
… a total of 48 cores (40 tumors/eight normal tissues) was purchased from US. US Biomax (catalog number BL481). Deidentified lung adenocarcinoma specimens were …
IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression
M Liu, DF Lee, CT Chen, CJ Yen, … — Mol. Cell, 2012
… TNFα-induced IKKα activities are independent of IKKβ. purchased from US Biomax. 2.3 …
FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
SY Lee, R Meier, S Furuta, ME Lenburg, … — J. Clin. Invest., 2012
… of normal and malignant (stages II and III) tissues were obtained from US Biomax …
67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis
M Kumazoe, K Sugihara, S Tsukamoto, Y Huang, … — J. Clin. Invest., 2013
… from Amersham Life Sciences. Patient tissue samples were purchased from US Biomax. Samples were incubated overnight at 4°C with the primary …
Nkx2-1 represses a latent gastric differentiation program in lung adenocarcinoma
EL Snyder, H Watanabe, M Magendantz, S Hoersch, … — Mol. Cell, 2013
… of the Department of Pathology at the Brigham and Women’s Hospital and US Biomax. Studies were carried out in accordance with protocols approved by the …
Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment
BA Hanks, A Holtzhausen, KS Evans, R Jamieson, … — J. Clin. Invest., 2013
… microarrays for human benign nevi and primary and metastatic melanomas (US Biomax, catalog no. ME1003) and both 4T1-sTGFBR3Tet and 66CL4 tumor …
Epithelial stem cell mutations that promote squamous cell carcinoma metastasis
RA White, JM Neiman, A Reddi, G Han, … — J. Clin. Invest., 2013
… to detect miR-9 in tissue arrays of human SCCs and SCC metastases (US Biomax). In normal head and neck tissue, miR-9–positive cells were …
A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity
P Li, F Du, LW Yuelling, T Lin, … — Nat. Neurosci., 2013
… to a standard procedure. Human medulloblastoma slides were purchased from US Biomax, …
Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis
J Xue, X Lin, WT Chiu, YH Chen, … — J. Clin. Invest., 2014
… breast primary carcinomas, and matched metastases in lymph nodes (BRM961; US Biomax) were used in this study. Immunohistochemical analyses were …
CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis
Y Lu, Y Wu, X Feng, R Shen, … — J. Clin. Invest., 2014
… lymphoma samples from The Ohio State University Department of Pathology and US Biomax, along with 10 normal LNs, were stained with antibodies specific to …
Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis
JB Wu, C Shao, X Li, Q Li, … — J. Clin. Invest., 2014
… with patient overall survival data, were obtained from Imgenex and US Biomax. Specimens were stained with antibodies specific for MAOA (Santa Cruz), …
The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer
ME Diefenbacher, N Popov, SM Blake, C Schülein-Völk, … — J. Clin. Invest., 2014
… slides containing 70 colon cancer samples and 10 controls were ordered from US Biomax (order no. CO811; http://www.US Biomax/tissue-arrays/Colon/CO811). For …
Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia
DH Wang, A Tiwari, ME Kim, NJ Clemons, … — J. Clin. Invest., 2014
… and esophageal squamous carcinoma from 11 patients was purchased from US Biomax (ES242). These tissue microarrays were submitted for …
Splicing factor SRSF6 promotes hyperplasia of sensitized skin
MA Jensen, JE Wilkinson, AR Krainer, , … — Nat. Struct. Mol. Biol., 2014
… in human tumors was performed with skin-cancer tissue microarrays (US Biomax) as described48. Staining intensities were scored by attributing score …
The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis
LE Young, S Sanduja, K Bemis-Standoli, EA Pena, … — Gastroenterology, 2009
… The colon cancer tissue array CO801 (US Biomax, Rockville, MD) contained 40 tissue cores each of colorectal adenocarcinomas and matched or unmatched …
KLF4α up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer
D Wei, L Wang, M Kanai, Z Jia, … — Gastroenterology, 2010
… higher percentage of KLF4α-positive staining was found in the tissues from US Biomax (Rockville, MD) than that from MD Anderson Cancer Center. …
Pan-histone deacetylase inhibitor panobinostat sensitizes gastric cancer cells to anthracyclines via induction of CITED2
I Regel, L Merkl, T Friedrich, E Burgermeister, … — Gastroenterology, 2012
… array ST843 of gastric cancer was purchased from US Biomax, Inc (Rockville, MD). Animals. (C) Cell survival analysis of pCITED2 and pcDNA3 …
Enhancer of zeste homolog 2 silences microRNA-218 in human pancreatic ductal adenocarcinoma cells by inducing formation of heterochromatin
CH Li, KF To, JH Tong, Z Xiao, … — Gastroenterology, 2013
… tissue microarray consisting of 87 PDAC cases and 10 normal cases (PA2082; US Biomax Inc, Rockville, …
MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy
C Lu, J Chen, HG Xu, X Zhou, … — Gastroenterology, 2014
… of the colon were provided by the University Hospital and purchased from US Biomax, Inc (BC05002; Rockville, …
Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway
Q Zhang, C Yu, S Peng, H Xu, … — Gastroenterology, 2014
… esophageal adenocarcinoma tissue arrays purchased from US Biomax (BC0211; Rockville, MD) containing 20 esophageal adenocarcinoma tissues with 20 …
Activation of EGFR and ERBB2 by Helicobacter pylori results in survival of gastric epithelial cells with DNA damage
R Chaturvedi, M Asim, MB Piazuelo, F Yan, … — Gastroenterology, 2014
… The second group consisted of TMAs of gastric tissues purchased from US Biomax, Inc (Rockville, …
Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells
CH Liao, CT Yeh, YH Huang, SM Wu, … — Hepatology, 2012
… 40 formalin-fixed liver tissues and 40 hepatocellular carcinoma samples (US Biomax, …
Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity
Y Guo, W Wang, J Wang, J Feng, … — Hepatology, 2013
… RACK1 (BD Biosciences, San Jose, CA) staining on tissue microarray slides (US Biomax, Rockville, MD; see …
MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer
H Peng, L Dara, TW Li, Y Zheng, … — Hepatology, 2013
… 48 colon cancers and their adjacent nontumorous tissues were obtained from US Biomax (Rockville, MD). Written informed consent was obtained from each …
Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer
J Wang, L Ma, W Weng, Y Qiao, … — Hepatology, 2013
… human liver cancer tissue microarray (TMA) slides were purchased from US Biomax (Rockville, MD). Slides …
Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice
S Sen, M Langiewicz, H Jumaa, NJ Webster, … — Hepatology, 2014
… human liver cancer tissue microarray (LV1503) was from US Biomax. H&E-stained sections were scored for inflammation, steatosis, and fibrosis according …
Connective tissue growth factor and integrin αvβ6: A new pair of regulators critical for ductular reaction and biliary fibrosis
L Pi, PM Robinson, M Jorgensen, SH Oh, … — Hepatology, 2014
… were from BioChain (Newark, CA) and human CC tissue arrays were from US Biomax, INC (Rockville, MD). Antibodies used for staining are listed in …
An epigenetic chromatin remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas
LV Pham, AT Tamayo, C Li, C Bueso-Ramos, … — Blood, 2010
… 100 cases of LBCL (single core per case; LY1001), were purchased from US Biomax. The tissue …
Latent KSHV infection increases the vascular permeability of human endothelial cells
C Guilluy, Z Zhang, PM Bhende, L Sharek, … — Blood, 2011
… upon VEGF Additionally, normal human skin slides were obtained from US Biomax, …
Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma
H Francis, S DeMorrow, J Venter, P Onori, … — Gut, 2012
… antibodies mentioned above, immunohistochemistry was performed in Accumax (US Biomax, Rockville, MD, USA) tissue arrays.26 Each tissue array contains 48 …
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
MA Jacobetz, DS Chan, A Neesse, TE Bapiro, … — Gut, 2013
… HA tissue microarray. Tissue microarrays were purchased from US Biomax Inc Rockville, MD, USA and stained with bHABP as described above. The …
Fluorescence endoscopic detection of murine colitis-associated colon cancer by topically applied enzymatically rapid-activatable probe
M Mitsunaga, N Kosaka, PL Choyke, MR Young, … — Gut, 2013
… types of colon disease. Colonic tissue microarray slide was obtained from US Biomax (Rockville, Maryland, USA), containing 20 cases of colon …
A novel anti-CD37 antibody-drug conjugate with multiple anti-tumor mechanisms for the treatment of B-cell malignancies
J Deckert, PU Park, S Chicklas, Y Yi, … — Blood, 2013
… with formalin-fixed, paraffin-embedded lymphoma tissue sections (US Biomax) after heat-induced antigen retrieval using murine anti-CD37 and …
Disease-specific gene repositioning in breast cancer
KJ Meaburn, PR Gudla, S Khan, SJ Lockett, … — J. Cell Biol., 2009
… were obtained from the AIDS and Cancer Specimen Resource or purchased from US Biomax, Imgenex Chromatin decondensation and nuclear reorganization of …
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion
N Sugiyama, E Gucciardo, O Tatti, M Varjosalo, … — J. Cell Biol., 2013
… tissue arrays containing paraffin-embedded tissue biopsies (BRM961; US Biomax) were stained with pretitrated dilutions of rabbit antibodies …
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function
C Jean, XL Chen, JO Nam, I Tancioni, … — J. Cell Biol., 2014
… normal breast and late-stage breast cancer tissue array (BR8013; US Biomax) sections were deparaffinized, rehydrated, processed for antigen …
Activation of anti-hepatitis C virus responses via Toll-like receptor 7
J Lee, CC Wu, KJ Lee, TH Chuang, … — Proc. Natl. Acad. Sci. U.S.A., 2006
… Pathologically confirmed human liver tissue arrays were obtained from US Biomax (Rockville, …
Links between alpha-catenin, NF-kappaB, and squamous cell carcinoma in skin
A Kobielak, E Fuchs, , — Proc. Natl. Acad. Sci. U.S.A., 2006
… (6). NF-κB Activation upon α-Catenin Ablation. hSCCs were from US Biomax, Rockville, MD. The MOM basic kit (Vector Laboratories) was used for …
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis
P Kelly, BJ Moeller, J Juneja, MA Booden, … — Proc. Natl. Acad. Sci. U.S.A., 2006
… Ki-67 staining; rate of apoptosis, as Tissue microarray (#BR801) was from US Biomax (Rockville, …
A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas
B Liu, E Park, F Zhu, T Bustos, … — Proc. Natl. Acad. Sci. U.S.A., 2006
… human skin SCC specimens and eight human skin arrays were purchased from US Biomax (Rockville, MD) and were immunohistochemically stained with anti-IKKα …
CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature
Z Miao, KE Luker, BC Summers, R Berahovich, … — Proc. Natl. Acad. Sci. U.S.A., 2007
… Tumor microarrays were purchased from Imgenex, Zymed/Invitrogen, Cybrdi, US Biomax, Biochain, and …
Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays
ME Hudson, I Pozdnyakova, K Haines, G Mor, … — Proc. Natl. Acad. Sci. U.S.A., 2007
… in healthy and cancerous tissues was performed by using tissue microarrays (US Biomax, Rockville, …
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
AC Kimmelman, AF Hezel, AJ Aguirre, H Zheng, … — Proc. Natl. Acad. Sci. U.S.A., 2008
… in Situ Hybridization. Tissue microarrays were purchased from Cybrdi or US Biomax. Fluorescence in situ hybridization was performed following standard …
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins
D Lam, D Dickens, EB Reid, SH Loh, … — Proc. Natl. Acad. Sci. U.S.A., 2009
… pancreatic cancer and normal pancreatic tissue arrays were obtained from US Biomax and processed for …
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
DS Markovic, K Vinnakota, S Chirasani, M Synowitz, … — Proc. Natl. Acad. Sci. U.S.A., 2009
… astrocytomas of all grades and tumor-free brain tissue was obtained from …
Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer
H Laklai, S Laval, L Dumartin, P Rochaix, … — Proc. Natl. Acad. Sci. U.S.A., 2009
… cores of 60 cases of pancreatic tumors and nine cases of normal pancreas (US …
RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia
DJ Shields, S Niessen, EA Murphy, A Mielgo, … — Proc. Natl. Acad. Sci. U.S.A., 2010
… was performed on 5-μm sections of primary tumors or human tissue arrays (US Biomax) according to the manufacturer's recommendations (Vector …
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells
S Hettmer, J Liu, CM Miller, MC Lindsay, … — Proc. Natl. Acad. Sci. U.S.A., 2011
… 2 h and were embedded in paraffin. Human tissue arrays were purchased from US Biomax (S02081). Sections were stained with H&E and for myogenin (1:100; …
Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism
A Cassago, AP Ferreira, IM Ferreira, C Fornezari, … — Proc. Natl. Acad. Sci. U.S.A., 2012
… Tissue Array and Cell Culture. Human normal and tumor breast tissue arrays (US Biomax) were subjected to immunohystochemical analysis with KGA and GAC …
Inactivation of androgen-induced regulator ARD1 inhibits androgen receptor acetylation and prostate tumorigenesis
Z Wang, Z Wang, J Guo, Y Li, … — Proc. Natl. Acad. Sci. U.S.A., 2012
… review board approval. The prostate tissue microarray was purchased from US Biomax. IHC, Immunoblotting, and …
β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas
C Yang, RR Iyer, AC Yu, RL Yong, … — Proc. Natl. Acad. Sci. U.S.A., 2012
… brain tumor and normal tissue array (US Biomax) were used to for immunohistochemistry staining. Normal brain tissue (n = 10), grade II glioma …
Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer
Y Peng, Y Dai, C Hitchcock, X Yang, … — Proc. Natl. Acad. Sci. U.S.A., 2013
… obtained from PN-S. Human NSCLC tissue arrays LC10012 were purchased from US …
Pla2g16 phospholipase mediates gain-of-function activities of mutant p53
S Xiong, H Tu, M Kollareddy, V Pant, … — Proc. Natl. Acad. Sci. U.S.A., 2014
… of Pla2g16 antibody on human tissue microarrays (OS804, slide no.14) from US …
Phospholipase Cδ1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells
R Satow, T Hirano, R Batori, T Nakamura, … — Proc. Natl. Acad. Sci. U.S.A., 2014
… tissue arrays with matched adjacent normal colon tissue were purchased from US Biomax (US Biomax). The immunostaining was performed as described previously …
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma
EY Chen, KP Dobrinski, KH Brown, R Clagg, … — PLoS Genet., 2013
… human primary rhabdomyosaroma (5 ERMS and 3 ARMS), US Biomax tissue microarray (14 ERMS and 4 ARMS, Rockville, MD), and a Children's Oncology …
NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3β resulting in the stabilization of MYCN in human neuroblastomas
Y Suenaga, SM Islam, J Alagu, Y Kaneko, … — PLoS Genet., 2014
… panel) upon depletion of MYCN in Tissue arrays (FDA808a-1 and FDA808a-2, US Biomax, Rockville, MD, USA) were used for the analyses of NCYM or MYCN …
FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs
SS Suh, JY Yoo, R Cui, B Kaur, … — PLoS Genet., 2014
… to TGF-β1 treatment. 192 and 80 lung cancer tissues were purchased from US Biomax, …
In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence
L Ménard, D Taras, A Grigoletto, V Haurie, … — J. Hepatol., 2010
… activity was evaluated using the Quantitative Telomerase Detection Kit (US Biomax) following instructions from the supplier. RT-QPCR. The inset shows …
Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis
X Ma, L Xu, S Wang, B Cui, … — J. Hepatol., 2011
… The human liver tissue microarrays were commercially provided by US Biomax instructions. The sequences of all used primers are available upon …
Acquisition of human-type receptor binding specificity by new H5N1 influenza virus sublineages during their emergence in birds in Egypt
Y Watanabe, MS Ibrahim, HF Ellakany, N Kawashita, … — PLoS Pathog., 2011
… human respiratory tract tissue sections were obtained from US Biomax (http://www.US Biomax/). The paraffin-embedded tissues were …
Differences in gastric carcinoma microenvironment stratify according to EBV infection intensity: implications for possible immune adjuvant therapy
MJ Strong, G Xu, J Coco, C Baribault, … — PLoS Pathog., 2013
… for EBER was performed on a gastric carcinoma tissue array (ST2091; US Biomax) in order to assess the presence of EBV. In the strongly EBV positive …
Negative regulation of lncRNA GAS5 by miR-21
Z Zhang, Z Zhu, K Watabe, X Zhang, … — Cell Death Differ., 2013
… pathway upon stimulation of Breast cancer TMAs were purchased from US Biomax (Rockville, MD, …
p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN
SW Hong, JH Moon, JS Kim, JS Shin, … — Cell Death Differ., 2014
… upon the ubiquitination system. The colon cancer TMAs were purchased from US Biomax, …
Transforming growth factor-beta signaling network regulates plasticity and lineage commitment of lung cancer cells
I Ischenko, J Liu, O Petrenko, MJ Hayman, … — Cell Death Differ., 2014
… to SSCs Lung Disease Spectrum Tissue arrays (BC041115a) were obtained from US Biomax (Rockville, MD, …
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation
M Abu-Remaileh, RI Aqeilan, , — Cell Death Differ., 2014
… (e) Representative samples from of breast cancer Tissue Micro Array (BR952, US Biomax) immunohistochemistry show inverse expression of GLUT1 and WWOX in human …
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling
S Hussain, O Foreman, SL Perkins, TE Witzig, … — Leukemia, 2010
… B-cell lymphoma tissue microarray was obtained from US Biomax. Mice L1. If UCH-L1 suppressed the transcription of PHLPP1, we would expect to see an …
Age-dependent labeling and imaging of insulin secretory granules
A Ivanova, Y Kalaidzidis, R Dirkx, M Sarov, … — Diabetes, 2013
… (Stressgen Biotechnologies), anti-glucagon (Sigma), and anti-somatostatin (US Biomax). 2.8 mmol/L glucose and 5 mmol/L KCl in HEPES buffer with 120 mmol/L …
Targeting the androgen receptor with siRNA promotes prostate cancer metastasis through enhanced macrophage recruitment via CCL2/CCR2-induced STAT3 activation
K Izumi, LY Fang, A Mizokami, M Namiki, … — EMBO Mol Med, 2013
… available human prostate TMA (PR243a and PR956) was purchased from US Biomax PSA values and survival data of some patients in these TMAs are …
Enhanced interferon signaling pathway in oral cancer revealed by quantitative proteome analysis of microdissected specimens using 16O/18O labeling and integrated two-dimensional LC-ESI-MALDI tandem MS
LM Chi, CW Lee, KP Chang, SP Hao, … — Mol. Cell Proteomics, 2009
… cell carcinoma tissues and three normal gingival tissues were obtained from US Biomax (Rockville, …
iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype
U Rajcevic, K Petersen, JC Knol, M Loos, … — Mol. Cell Proteomics, 2009
… tissue microarray of primary gliomas and normal human brain tissue (GL208, US Biomax, Rockville, MD) was …
Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies
AA Shah, A Rosen, L Hummers, F Wigley, … — Arthritis Rheum., 2010
… findings. Normal breast and ovary paraffin sections were purchased from US Biomax. Cancerous and normal tissue sections were stained with a monoclonal …
CD90 is identified as a candidate marker for cancer stem cells in primary high-grade gliomas using tissue microarrays
J He, Y Liu, T Zhu, J Zhu, … — Mol. Cell Proteomics, 2012
… samples were provided in the form of tissue microarrays (US Biomax For double immunofluorescence staining of CD90 and CD31, a mixture of mouse …
Proteomic analysis of temporally stimulated ovarian cancer cells for biomarker discovery
MA Marzinke, CH Choi, L Chen, IeM Shih, … — Mol. Cell Proteomics, 2013
… stage and histological type of the TMA cases was provided by the company (US Biomax). OVCAR3 cells were treated with EGF (50 ng/ml) and/or the PI3K/Akt …
Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression
P Saraon, D Cretu, N Musrap, GS Karagiannis, … — Mol. Cell Proteomics, 2013
… microarrays consisting of 8 normal and 40 cancer cores were purchased from US Biomax (Rockville, …
Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice
TV Kalin, IC Wang, TJ Ackerson, ML Major, … — Cancer Res., 2006
… mouse prostate tissue or human prostate cancer tissue microarrays (US Biomax, Ijamsville, MD) were stained with H&E or used for …
The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer
IM Kim, T Ackerson, S Ramakrishna, M Tretiakova, … — Cancer Res., 2006
… and the Custom Non–Small Cell Lung Carcinoma TMA human tissue array (US Biomax, Rockville, MD) using mouse monoclonal antibodies specific for …
Extracellular matrix-mediated membrane-type 1 matrix metalloproteinase expression in pancreatic ductal cells is regulated by transforming growth factor-beta1
AJ Ottaviano, L Sun, V Ananthanarayanan, HG Munshi, … — Cancer Res., 2006
… IN). Immunohistochemistry. Pancreatic tissue microarrays were obtained from US Biomax (Rockville, MD) and consisted of 70 tissue cores measuring 1.5 mm in …
Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells
Y Kim, JW Yoon, X Xiao, NM Dean, … — Cancer Res., 2007
… analysis of Gli2. Human HCC tissue arrays were purchased from US Biomax (Rockville, MD). Liver was taken either from 3-month-old …
Interleukin-4 cytotoxin therapy synergizes with gemcitabine in a mouse model of pancreatic ductal adenocarcinoma
T Shimamura, RE Royal, M Kioi, A Nakajima, … — Cancer Res., 2007
… 70 tumor specimens were obtained from Cooperative Human Tissue Network and US Biomax, …
Polo-like kinase 1 is involved in invasion through extracellular matrix
A Rizki, JD Mott, MJ Bissell, , … — Cancer Res., 2007
… (UCSF), Breast Specialized Program of Research Excellence, tissue core, or US Biomax as 5-μm-thick serial …
Galectin-3 cleavage: a novel surrogate marker for matrix metalloproteinase activity in growing breast cancers
P Nangia-Makker, T Raz, L Tait, V Hogan, … — Cancer Res., 2007
… sections were part of a breast cancer progression tissue array (BR480) from US Biomax. The H64P mutant produced a ∼27-kDa polypeptide upon incubation with …
Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis
T Yokoe, F Tanaka, K Mimori, H Inoue, … — Cancer Res., 2008
… paraffin-embedded section of normal human testis was purchased from US Biomax (HuFPT151). A section of normal human testis was purchased from US …
Rad9 has a functional role in human prostate carcinogenesis
A Zhu, CX Zhang, HB Lieberman, , … — Cancer Res., 2008
… US Biomax Furthermore, overexpression of Rad9 in the nontumorigenic, immortalized human prostate cell line PWR-1E conferred upon those cells the …
CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism
WL Jamieson, S Shimizu, JA D'Ambrosio, O Meucci, … — Cancer Res., 2008
… and tissue array analysis. Tissue microarrays were obtained from US Biomax, …
Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells
TR Graham, HE Zhau, VA Odero-Marah, AO Osunkoya, … — Cancer Res., 2008
… microarrays. The prostate cancer tissue microarrays were purchased from US Biomax. Detection of ZEB1 of normal and prostate tumor tissue specimens was …
Targeting a tumor-specific laminin domain critical for human carcinogenesis
M Tran, P Rousselle, P Nokelainen, S Tallapragada, … — Cancer Res., 2008
… microarrays from skin (SK802) and multiple organs (BC00019) obtained from US Biomax, were inhibitor IκBα, which produces transformed cells that …
Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2
J Chen, F Deng, SV Singh, QJ Wang, … — Cancer Res., 2008
… specimens and normal human prostate tissue samples were purchased from US Biomax. Cell proliferation was determined by counting the number of viable …
Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity
KA Link, S Balasubramaniam, A Sharma, CE Comstock, … — Cancer Res., 2008
… using a tissue microarray (TMA) slide containing 80 cores (PR801; US Biomax). Patient tumors and the TMA were evaluated, graded, and …
Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors
RC Pezo, SJ Gandhi, LA Shirley, RG Pestell, … — Cancer Res., 2008
… from 15 anonymous colon cancer patients in triplicate were purchased (US Biomax). …
Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation
D Zheng, YY Cho, AT Lau, J Zhang, … — Cancer Res., 2008
… The Human Brain Glioblastoma Tissue Microarray was purchased from US Biomax, and the Cy3-conjugated donkey anti-rabbit IgG antibody was …
Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis
YK Kang, R Schiff, L Ko, T Wang, … — Cancer Res., 2008
… and Methods. Immunohistochemical analyses. Tumor arrays were purchased from US Biomax (KD991). All small interfering RNA (siRNA) oligos were purchased from …
Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study
V Balan, P Nangia-Makker, AG Schwartz, YS Jung, … — Cancer Res., 2008
… array (BR480) containing 48 tissue cores of 2-mm size was purchased from US Biomax. Four-micrometer serial sections …
CXCR6 induces prostate cancer progression by the AKT/mammalian target of rapamycin signaling pathway
J Wang, Y Lu, J Wang, AE Koch, … — Cancer Res., 2008
… tissue microarrays were constructed by US Biomax Upon activation, mTOR, a serine/threonine kinase, is responsible for phosphorylation and …
The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer
H Shen, N Powers, N Saini, CE Comstock, … — Cancer Res., 2008
… microarrays containing benign and malignant tissue cores were obtained from US Biomax (PR801 Despite these observations, cross-comparison with published data …
Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis
AM Bode, YY Cho, D Zheng, F Zhu, … — Cancer Res., 2009
… bromide staining. Immunostaining. A human skin cancer tissue array (5 μm; US Biomax) and mouse dorsal skin samples (100 μm) were processed and …
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness
C Jin, YA Yang, MR Anver, N Morris, … — Cancer Res., 2009
… cancer tissue array BR801 with matching normal tissues was from US Biomax of activated HRas-transformed MCF-10A cells ( 6). MCF10Ca1a cells …
Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival
W Xian, L Pappas, D Pandya, LM Selfors, … — Cancer Res., 2009
… sets of human ILC using tissue microarrays that were purchased from US Biomax (BR805 and …
Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas
HJ Jun, S Woolfenden, S Coven, K Lane, … — Cancer Res., 2009
… tissue micro arrayss [US Biomax and ISU-ABXIS (Accumax)] were processed for immunohistochemistry as follows: after target retrieval, endogenous …
Androgen-induced coactivator ANCCA mediates specific androgen receptor signaling in prostate cancer
JX Zou, L Guo, AS Revenko, CG Tepper, … — Cancer Res., 2009
… microarray slides were obtained from US Biomax Tumors were evaluated and graded by pathologists according to guidelines ( 27). Results. ANCCA is …
Biological significance of prolactin in gynecologic cancers
VV Levina, B Nolen, Y Su, AK Godwin, … — Cancer Res., 2009
… Chemicals. Cancer and normal tissue microarrays (TMA) were purchased from US Biomax, …
Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression
W Yue, Q Sun, R Landreneau, C Wu, … — Cancer Res., 2009
… Tissue microarray slides (US Biomax) are described in Supplementary Table S1. investigated. Tumor metastasis is stimulated upon inactivation of a …
Functional significance of secreted Frizzled-related protein 1 in metastatic renal cell carcinomas
S Saini, J Liu, S Yamamura, S Majid, … — Cancer Res., 2009
… paraffin-embedded renal carcinoma progression tissue microarray (US Biomax). The slides were deparaffinized and …
Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis
S Saini, H Hirata, S Majid, R Dahiya, … — Cancer Res., 2009
… paraffin-embedded endometrial cancer tissue arrays (EMC241 and EMC962; US Biomax). These included 12 cases …
Functional significance of Wnt inhibitory factor-1 gene in kidney cancer
K Kawakami, H Hirata, S Yamamura, N Kikuno, … — Cancer Res., 2009
… and matched adjacent tissue 1.5 cm away from carcinoma was obtained from US Biomax (KD481). Detailed information on all …
Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer
YW Huang, JC Liu, DE Deatherage, J Luo, … — Cancer Res., 2009
… total of 74 endometrial tumors and 20 normal specimens, were obtained from US Biomax. Patients' characteristics were summarized in Supplementary Table …
Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells
Y Kimura, T Morita, K Hayashi, T Miki, … — Cancer Res., 2010
… A microarray tissue section slide (SO2081, US Biomax) that included samples of human leiomyosarcomas and normal smooth muscle tissue was …
Role of secreted frizzled-related protein 3 in human renal cell carcinoma
H Hirata, Y Hinoda, K Ueno, S Majid, … — Cancer Res., 2010
… Tissue microarray analysis. We purchased a kidney tissue microarray from US Biomax. This tissue microarray included 5 normal human kidney tissues, 26 …
Pituitary tumor transforming gene binding factor: a new gene in breast cancer
RJ Watkins, ML Read, VE Smith, N Sharma, … — Cancer Res., 2010
… examination of PBF staining in three normal breast samples (N1–N3; US Biomax; ×40 original magnification) and three tumor samples from These data …
FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer
PS Ray, J Wang, Y Qu, MS Sim, … — Cancer Res., 2010
… expression in human breast cancer tissue microarrays (BRC961 and BR962, US Biomax) and in 42 archived triple-negative human breast cancer specimens from …
CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer
MJ Meyer, JM Fleming, AF Lin, SA Hussnain, … — Cancer Res., 2010
… and confocal microscopy. Two human breast tumor tissue microarrays (US Biomax) were used for analysis; each contained 2 invasive lobular and 35 …
Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis
T Sinnberg, M Menzel, S Kaesler, T Biedermann, … — Cancer Res., 2010
… YO-PRO-1. For immunohistochemistry of the tissue array (ME1001-5-BX US Biomax), the reaction …
CAV1 inhibits metastatic potential in melanomas through suppression of the integrin/Src/FAK signaling pathway
C Trimmer, D Whitaker-Menezes, G Bonuccelli, JN Milliman, … — Cancer Res., 2010
… of paraffin-embedded human melanoma tissue samples were purchased from US Biomax (Mel207; 69 cases/207 cores) and was stained for CAV1(N-20) using …
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation
N Sugiyama, M Varjosalo, P Meller, J Lohi, … — Cancer Res., 2010
… and normal frozen tissue arrays (FMC401 and BRF401; US Biomax) were stained with pretitrated dilutions of polyclonal anti-FGFR4 antibodies (Santa …
Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement
RA Whipple, MA Matrone, EH Cho, EM Balzer, … — Cancer Res., 2010
… Biorepository and Research Core as well as a human breast cancer TMA (US Biomax) containing …
The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor
N Ferrand, A Atfi, C Prunier, , … — Cancer Res., 2010
… hundred sections from skin tissue array (US Biomax) were studied. cells in which TGF-β–induced signaling is highly sensitive to the amount of c-Ski, as …
Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling
RS Wahdan-Alaswad, K Song, TL Krebs, DT Shola, … — Cancer Res., 2010
… cores from a human prostate tissue microarray (PR8011 series) obtained from US Biomax, …
Human RecQL4 helicase plays critical roles in prostate carcinogenesis
Y Su, JA Meador, GM Calaf, L Proietti De-Santis, … — Cancer Res., 2010
… prostate tissue panel array slides (PR951 and PR751) were procured from US Biomax Fluorescence in situ hybridization and immunohistochemistry. …
ANCCA/ATAD2 overexpression identifies breast cancer patients with poor prognosis, acting to drive proliferation and survival of triple-negative cells through control of B-Myb and EZH2
EV Kalashnikova, AS Revenko, AT Gemo, NP Andrews, … — Cancer Res., 2010
… tumor tissue microarrays (TMA; BR1002, BR961, and BR208) were obtained from US Biomax, baked at 60°C for 2 hours cells showed that most of these genes …
Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype
KM Hardy, DA Kirschmann, EA Seftor, NV Margaryan, … — Cancer Res., 2010
… Serial sections of a melanoma tissue array (ME1003) were purchased from US Biomax and stained for Notch4 or Nodal expression …
p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase
HG Yu, JO Nam, NL Miller, I Tanjoni, … — Cancer Res., 2011
… of paxillin upon orthotopic implantation Micro-array slides (US Biomax; CO1002, CO701, CO2085a) with colon tumor (with clinical stage and …
LATS2 is a tumor suppressor gene of malignant mesothelioma
H Murakami, T Mizuno, T Taniguchi, M Fujii, … — Cancer Res., 2011
… human mesothelioma tissue array with 19 MM samples was also used (US Biomax). Preparation of DNA and RNA. The primer sets of NF2 were described …
TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer
B Salaun, L Zitvogel, C Asselin-Paturel, Y Morel, … — Cancer Res., 2011
… routine detection of TLR3 Melanoma tissue microarrays were purchased from US Biomax (TMA ME#802 and ME#241) and Tristar (TMA …
Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers
W Li, L Wang, H Katoh, R Liu, … — Cancer Res., 2011
… used at 1:200. FOXP3 and Lats2 staining of tissue microarray (TMA) samples (US Biomax) were scored double blind. DNA sequencing for human YAP gene in …
Activation of Toll-like receptor 5 on breast cancer cells by flagellin suppresses cell proliferation and tumor growth
Z Cai, A Sanchez, Z Shi, T Zhang, … — Cancer Res., 2011
… T082) including 75 individual breast cancer specimens were purchased from US Biomax. Interestingly, we found that upon flagellin stimulation, there was a …
A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis
HF Langer, VV Orlova, C Xie, S Kaul, … — Cancer Res., 2011
… A Tissue Microarray Kit (ME1001; US Biomax) was used. This kit contained samples from 56 patients with malignant melanomas, 20 …
Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity
S Singh, Z Wang, D Liang Fei, KE Black, … — Cancer Res., 2011
… to an Institutional Review Board–approved protocol or purchased (US Biomax) and then The expression of HH target genes and their subsequent …
Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas
T Pulvirenti, M Van Der Heijden, LA Droms, JT Huse, … — Cancer Res., 2011
… a tissue TMA containing glioblastoma and normal brain samples was used (US Biomax, GL806). The fact that this phenotype was not observed upon a block of …
LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells
Y Ward, R Lake, JJ Yin, CD Heger, … — Cancer Res., 2011
… and in matched normal adjacent tissue in a prostate cancer tissue array (US Biomax). To determine whether CD97-stimulated SRE activity was dependent …
Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG4
X Wang, A Katayama, Y Wang, L Yu, … — Cancer Res., 2011
… previously (16). Normal tissue microarray (Cat#FBN401) was purchased from US Biomax Monoclonal and polyclonal antibodies, scFv antibodies, and …
Genetically modified T cells targeting interleukin-11 receptor α-chain kill human osteosarcoma cells and induce the regression of established osteosarcoma lung metastases
G Huang, L Yu, LJ Cooper, M Hollomon, … — Cancer Res., 2012
… microarray slides of human normal tissues were purchased from US Biomax …
A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis
C Huang, Z Qiu, L Wang, Z Peng, … — Cancer Res., 2012
… was analyzed using human pancreatic cancer and normal tissue microarray (US Biomax). The use of …
Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer
YY Zaytseva, PG Rychahou, P Gulhati, VA Elliott, … — Cancer Res., 2012
… of actin cytoskeleton upon FASN inhibition. The CO702 tissue array (US Biomax), A203 (IV) tissue array (AccuMax), and FASN antibody (Cell Signaling) …
miRNA signatures associate with pathogenesis and progression of osteosarcoma
KB Jones, Z Salah, S Del Mare, M Galasso, … — Cancer Res., 2012
… validation was carried out using a bone cancer tissue microarray (US Biomax) that included 8 core tissue sections from 4 OSs. Two of the OS …
Epidermal growth factor receptor variant III contributes to cancer stem cell phenotypes in invasive breast carcinoma
CA Del Vecchio, KC Jensen, RT Nitta, AH Shain, … — Cancer Res., 2012
… microarray was obtained containing 60 cases of invasive breast carcinoma (US Biomax, catalog no. This phenomenon was reversible upon the addition of …
KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer
JA Kelber, T Reno, S Kaushal, C Metildi, … — Cancer Res., 2012
… Human pancreatic cancer tissue array was purchased from US Biomax Viable cell number was measured on days 3 or 8 based upon CyQuant …
Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence
KT Lin, J Gong, CF Li, TH Jang, … — Cancer Res., 2012
… protocol) or from commercial prostate cancer tissue arrays (US Biomax Endogenous Vav3 was associated with EphA2 upon ephrinA1-Fc …
DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
Q Lv, W Wang, J Xue, F Hua, … — Cancer Res., 2012
… Human breast or colon cancer tissue microarray slides (US Biomax) were detected as previously described (27). Chemoinvasion …
Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling
B Hu, MS Nandhu, H Sim, PA Agudelo-Garcia, … — Cancer Res., 2012
… of formalin-fixed, paraffin-embedded glioma specimens were purchased from US Biomax, yielding 65 increasing amounts of the NICD fragment, the upregulation …
INK4a/ARF [corrected] inactivation with activation of the NF-κB/IL-6 pathway is sufficient to drive the development and growth of angiosarcoma
J Yang, S Kantrow, J Sai, OE Hawkins, … — Cancer Res., 2012
… vascular tissue microarray from US Biomax and MD Anderson Cancer Center (University of Texas, Houston, Texas) were examined for RelA Anti-IL-6 not only …

Tissue microarray technology:

  1. Holger Moch, Juha Kononen, Olli-P. Kallioniemi, and Guido Sauter, Tissue microarrays: what will they bring to molecular and anatomic pathology. Advances in Anatomic Pathology Vol.8, No.1,14-20, (2001).
  2. Ronald Simon, Jan Richter, Urs Wagner, et al., High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy numberalterations in urinary bladder cancer. Cancer Res. 61:4514-4519, (2001).
  3. Mark A. Rubin. Use of laser capture microdissection, cDNA microarrays,and tissue microarrays in advancing our understanding of prostateCancer. J. Pathol. 195:80-86, (2001).
  4. Olli-P. Kallioniemi, Urs Wagner, Juha Kononen and Guido Sauter, Tissue microarray technology for high-throughput molecular profiling of cancer. Human Molecular Genetics Vol.10, No.7, 657-662, (2001).
  5. David L. Rimm, Robert L. Camp, Lori A.Charette, et al., Tissue microarray: a new technology for amplification of tissue resources. The Cancer Journal Vol.7, No.1, (2001).
  6. Lukas Bubendorf, Antonio Nocito, Holger Moch and Guido Sauter, Tissue microarray (TMA) technology: miniaturized pathology archives for high -Throughput in situ studies. J. Pathol. 195:72-79, (2001).
  7. Chad R. Englert, Galina V. Baibakov, and Michael R. Emmert-Buck, Cancer Res. 60:1526-1530, (2000).
  8. F. von Eggeling, H. Davies, L. Lomas, W. Fiedler, K. Junker, U. Claussen and G. Ernst, Tissue-specific microdissection coupled with proteinchip array technologies: applications in cancer research. Biotechniques Vol.29, No.5, 1066-1070, (2000).
  9. Olivier Braissant and Walter Wahli, A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections. Biochemica No.1, 10-16, (1998).